Iranian defense minister has dismissed the recent remarks on regime change by US defense chief against the Islamic Republic, saying they run counter to all principles of the international law.

Brigadier General Hossein Dehqan said the recent remarks by Jim Mattis are meddlesome and disgraceful. He added that Instead of ordering other nations around, the US defense chief and Trump's administration had better think about ways to solve the country's domestic issues and study their root causes.

In a statement on Tuesday Dehqan noted that such internal issues would most probably lead to the collapse of the sitting US government in the near future and pose numerous and serious challenges to the country's political system.

The Iranian defense minister said individuals such as the US defense secretary have an arrogant and bullying nature, overlook the power of nations and ignore historical facts and these factors have robbed them of their common sense. He added that comments by Mattis can only be made by deranged person.

Meanwhile, Iranian Foreign Ministry Spokesman Bahram Qassemi also on Tuesday dismissed Mattis's thoughtless and unfounded remarks, saying the US government's policies and its support for terrorist-nurturing regimes are the root causes of extremism and terrorism.

Terrorism and extremism in the region and in the world are rooted in the US thoughtless policies in supporting terrorist-nurturing countries and the state terrorism of the Zionist regime of Israel, he said.

He rejected an unfounded allegation leveled by Mattis about Iran's alleged efforts in the past to murder the Saudi ambassador in downtown Washington, saying the US, itself, had drawn up the plot with the support of one of the regional countries.

The Iranian spokesperson said Mattis has repeatedly accused Iran of supporting terrorism while the US establishment and its current defense secretary, himself, are the symbols of terrorism and violation of human rights.

Addressing a high school journalism student in Mercer Island, a Seattle suburb on Monday, Mattis called for a regime change in Iran as a prerequisite for restoration of Tehran-Washington ties.

In November 1979 and in less than a year after the victory of the Islamic Revolution that toppled the US-backed Pahlavi monarchy, Iranian university students seized the US embassy in Tehran.

The students believed the US mission had turned into a center of spying aimed at overthrowing the Islamic establishment in Iran following the Islamic Revolution earlier that year.

Documents found at the compound later confirmed assertions by Iranian students that Washington was using its embassy in Tehran to plot against the new Islamic Republic of Iran. The spying scandal led to the severing of ties between the two countries.