The latest attack comes after U.S. forces struck ISIS infrastructure and weapons sites last month in retaliation for the deaths of two U.S. soldiers and a civilian interpreter.

The U.S. has carried out what it called "large-scale strikes" against ISIS in Syria, U.S. Central Command announced Saturday afternoon.

The strikes, conducted at around 12:30 p.m. ET, were part of Operation Hawkeye Strike, which the Pentagon said was ordered by President Donald Trump on Dec. 19 in response to an ISIS ambush near Palmyra on Dec. 13. That attack killed two U.S. soldiers and a U.S. civilian interpreter, U.S. officials said.

The military in December launched strikes against Islamic State group infrastructure and weapons.

CENTCOM spokesperson Capt. Tim Hawkins told NBC News that more than 35 targets were struck in Saturday`s operation. More than 90 precision munitions were fired, and more than 20 aircraft were involved.

Defense Secretary Pete Hegseth posted about the strikes on X, saying, "We will never forget, and never relent."

The military said the strikes targeted ISIS "as part of our ongoing commitment to root out Islamic terrorism against our warfighters, prevent future attacks, and protect American and partner forces in the region."

"Our message remains strong: if you harm our warfighters, we will find you and kill you anywhere in the world, no matter how hard you try to evade justice," CENTCOM`s statement said.

Three other U.S. personnel were wounded in the December ambush, prompting Trump to vow retaliation, calling it "an ISIS attack against the U.S." The Defense Department said the incident happened during a counterterrorism engagement.

Trump announced strikes on Syria the week after, saying the U.S. was "inflicting very serious retaliation." NBC News previously reported, per two U.S. officials, that the strikes were expected to last several weeks or up to a month.

Hegseth said in December that the operation was not "the beginning of a war - it is a declaration of vengeance."