A Syrian soldier stands guard on a main road leading to the town of Rastan in the central Homs province. (AFP)

A drone attack on a Syrian military academy in the country’s western city of Homs has killed at least 100 people and left many others wounded, reports say.

The army confirmed that several drones targeted the graduation ceremony attended by cadets’ families in Homs on Thursday.

It said that armed terrorist organizations targeted the graduation ceremony e attack was carried out by terrorist groups.

The Syrian armed forces said the attack was unprecedented, adding it was carried out by explosive laden drones.

The army promised to respond with full force and determination, warning that those who planned and executed the attack will pay dearly.

There were dozens of wounded soldiers, with critical injuries among the invited families, including women and children, in addition to a number of college students participating in the graduation, the defense ministry said in a separate statement.

It also said that terrorist organizations supported by well-known international parties have carried out the attack.

No group has yet claimed responsibility for the attack.

Observers say the attack was launched from areas northwest of Homs. It came one day after Syrian army forces carried out a string of military operations against terrorist bases and arms depots in the northwestern Province of Idlib.

Dozens of terrorists, among them high-profile commanders, were killed in the operation, accordion to Syrian defense ministry.