An 18-month-old Palestinian girl, who lost one of his legs, struggles to survive under difficult conditions at the Al-Ehli Baptist Hospital, where he is receiving treatment in Gaza City, Gaza on July 25, 2025. (Via AFP)

At least 21,000 Palestinian children have been left disabled or amputated since the Israeli regime unleashed its genocidal war against the people of Gaza in October 2023.

According to figures shared by Mohamad Safa, Executive Director and Main Representative of PVA to the United Nations ECOSOC in New York, more than 40,500 children have suffered new war-related injuries in Gaza.

He said over 56,348 children have also been orphaned during the two years of war.

Safa also warned that acute hunger is spreading rapidly in Gaza and tens of thousands of children now depend entirely on humanitarian support.

At least 21,000 Palestinian children have been disabled or amputees, around 40,500 children have suffered "new war-related injuries", with over 56,348 Palestinian children have been orphaned in Gaza since October 7, 2023.

These are crimes against humanity. pic.twitter.com/dxpht5a4yH

� Mohamad Safa (@mhdksafa) December 6, 2025

In a separate post on social media platform X, Safa urged urgent donations to help families who are "on the brink."

He warned that children are facing starvation alongside untreated injuries and trauma.

Palestinians are not "facing" starvation.

They are being starved to death by Israel.

Forced starvation is an act of genocide. pic.twitter.com/qz25hYQ299

� Mohamad Safa (@mhdksafa) December 6, 2025

The Integrated Food Security Phase Classification (IPC) declared a state of catastrophic famine in Gaza earlier this year. While limited aid has trickled into the territory since October, experts warn that the famine`s impact could fundamentally alter Gaza for generations.

In a related development, the United Nations called for an investigation into Israel`s killing of two boys in the so-called yellow line in Gaza on Saturday. The regime`s forces shot dead two brothers aged eight and ten in a drone strike east of Khan Younis.

The boys were sent out to gather firewood for the family, their father told CNN, but never returned. He said his kids` small bodies were torn to pieces by the blast.

Israel later acknowledged the attack, claiming the children had crossed the so-called yellow line.

UN spokesperson Stéphane Dujarric described the killing of the children as "horrific," saying it was "hard to see how two boys, eight and 10, can be considered a threat."

Dujarric called for a full investigation and accountability into the attack.

The so-called yellow line, a ceasefire demarcation line established under the US-brokered agreement for Israel`s withdrawal, has become a deadly frontier in Gaza, where Israeli forces are forcing residents from entire eastern districts and blocking their return.

Hamas has said previously that the zone has become a deadly frontier in the Palestinian territory.

Palestinians say the line changes without warning, turning areas considered safe one day into deadly zones the next. Dozens have been killed in recent months after inadvertently entering the area.

Two months into the ceasefire agreement, rights groups and ceasefire monitors say the regime`s genocide in Gaza has not stopped. They report more than 500 violations of the ceasefire, with at least 356 Palestinians killed during this period, pushing Gaza`s overall death toll to more than 70,000, including more than 20,000 children.

Independent researchers estimate the real death toll could exceed 100,000, given the thousands of bodies still buried under rubble.